Voriconazole (Vfend) 200/40mg | Pfizer Germany Originator | GLT

Generic Information: Vfend (Germany)

Vfend is the originator brand of voriconazole, a broad-spectrum triazole antifungal discovered and marketed by Pfizer. This Germany-sourced presentation is supplied as oral tablets in two strengths — 200 mg and 40 mg — the latter for paediatric dosing or reduced-weight adults. Voriconazole was the first modern triazole with dependable activity against Aspergillus moulds, and it remains a first-line option for invasive aspergillosis worldwide.

What Is Voriconazole (Vfend) Used For?

Voriconazole treats serious fungal infections that mostly strike patients with weakened immunity: invasive aspergillosis, candida bloodstream infection in non-neutropenic patients, oesophageal candidiasis, and infections caused by Fusarium or Scedosporium species that resist older azoles. Because it is active both against yeasts and moulds, it is a workhorse in haematology, transplant and intensive-care settings where an unidentified fungus must be covered quickly.

How Does Voriconazole Work?

Fungi need ergosterol to keep their cell membranes intact. Voriconazole blocks lanosterol 14-alpha-demethylase, the fungal enzyme that builds ergosterol, starving the membrane of its key structural lipid and stopping growth; against many pathogens the effect is fungicidal. Its target is selective for fungal cells, so the drug is tolerated even at the high loading doses used to reach therapeutic blood levels within the first day of treatment.

Indications

The approved indications span invasive aspergillosis, candidemia in non-neutropenic patients, deep-tissue Candida infection, oesophageal candidiasis, and serious Fusarium or Scedosporium apiospermum infection where other therapy has failed or is not tolerated. Treatment decisions rest with infectious-disease specialists, who confirm the organism by culture or biomarker and adjust based on therapeutic drug monitoring, since voriconazole blood levels vary widely between patients.

Dosage

Adults receive a loading dose of 6 mg/kg every 12 hours for the first 24 hours — intravenously or as oral tablets — then a maintenance dose of 4 mg/kg twice daily intravenously or 200 mg every 12 hours by mouth. Adults under 40 kg take a reduced oral maintenance dose of 100 to 150 mg twice daily. The 40 mg tablet strength supports weight-based adjustments and paediatric regimens, and dosing is halved in mild-to-moderate liver impairment.

Side Effects

Common effects include visual disturbance such as blurred vision or increased light sensitivity, which is usually transient, together with nausea, fever, rash, headache and abnormal liver tests. Serious but less frequent risks are liver toxicity, QT prolongation with heart-rhythm disturbance, and skin reactions worsened by sunlight — patients are advised to avoid strong sun exposure during therapy. Blood levels, liver function and visual symptoms are monitored throughout the course.

Storage

Vfend tablets are stored at controlled room temperature in their original sealed containers, away from moisture and heat, with no refrigeration required. Tablets travel safely by ambient-condition courier, and GLT ships from a Hong Kong-licensed facility with batch documentation and a certificate of analysis enclosed.

Why Choose Vfend Through GLT?

For hospitals and importing pharmacies, the German originator presentation offers Pfizer's reference-standard voriconazole with European regulatory provenance and full traceability. GLT's Hong Kong base supports temperature-stable tablet logistics across regions, and the 200 mg and 40 mg strengths cover both standard adult and weight-adjusted dosing in a single listing.

How to Order

To order Vfend (voriconazole) from GLT, contact us on WhatsApp at +86 15234153837 or by email at [email protected]. We confirm stock, pack options and delivery timelines to your country, and dispatch from a Hong Kong-licensed facility.

FAQ

Is Vfend the original voriconazole? Yes — Vfend is Pfizer's originator brand, first approved in 2002 and still the reference product for voriconazole.

Why two tablet strengths? 200 mg covers standard adult maintenance dosing, while 40 mg supports weight-based and paediatric adjustments.

Do I need blood-level monitoring? Yes — voriconazole levels vary between patients, so therapeutic drug monitoring is standard practice in serious infections.