Yixinke (Sirolimus) 0.5mg Tablets | China Generic | GLT

Generic Information: Yixinke (Sirolimus) — North China Pharmaceutical Generic

Yixinke (宜欣可) is a domestically developed sirolimus product manufactured by North China Pharmaceutical Company, Ltd. (华北制药), one of China's oldest and largest state-owned pharmaceutical enterprises. This page covers the 0.5 mg tablet presentation in a 20-tablet pack. Yixinke delivers the same mTOR inhibitor mechanism as the originator Rapamune but at a more accessible cost, making it a widely used domestic alternative for transplant patients who require lifelong immunosuppression. North China Pharmaceutical has invested over two decades developing its sirolimus manufacturing capability, producing a bioequivalent product that has been trusted in Chinese clinical practice for many years.

What Is Yixinke (Sirolimus) Used For?

Yixinke is used for the prevention of organ rejection after kidney transplantation, typically in combination with other immunosuppressants such as ciclosporin and corticosteroids. The 0.5 mg strength is particularly useful for fine dose adjustment, which is important because sirolimus requires therapeutic drug monitoring to keep whole-blood trough levels within a narrow target range. As a bioequivalent domestic product, Yixinke provides the same immunosuppressive effect as the originator at a fraction of the cost, helping reduce the long-term financial burden of transplantation.

How Does Yixinke (Sirolimus) Work?

Yixinke contains sirolimus, which binds FKBP-12 and inhibits mTOR, the kinase that drives the proliferation of activated T-lymphocytes. By suppressing this pathway, sirolimus reduces the immune response against a transplanted kidney and lowers the risk of rejection. Because sirolimus has a narrow therapeutic window, the 0.5 mg tablet allows precise dose titration in response to blood-level monitoring, which is a practical advantage for clinicians managing individual patient needs.

Indications

Yixinke (sirolimus) is indicated for the prophylaxis of organ rejection in patients receiving a kidney transplant, used in combination with ciclosporin and corticosteroids. It is a bioequivalent domestic alternative to the originator Rapamune.

Dosage

The usual maintenance dose of sirolimus is 2 mg once daily after a loading dose, individualized to achieve whole-blood trough levels of 4–12 ng/mL. The 0.5 mg tablet is used for fine dose adjustment and for patients who require reduced dosing. The tablet should be taken at the same time each day, consistently with or without food, and must not be crushed or chewed. Therapeutic drug monitoring is essential throughout treatment.

Side Effects

The side-effect profile of Yixinke matches that of sirolimus generally: peripheral edema, hyperlipidemia, hypertension, and impaired wound healing are common, along with stomatitis, diarrhea, and an increased risk of infection. Patients require regular monitoring of blood counts, kidney function, and lipid levels. Any new cough, breathlessness, or signs of infection should be reported promptly.

Storage

Store Yixinke tablets in the original packaging, protected from light and moisture. Keep out of reach of children and do not use beyond the expiry date.

Why Choose the GLT?

Yixinke represents the highest-quality domestic sirolimus option, backed by North China Pharmaceutical's decades of manufacturing experience and bioequivalence to the originator. Compared with brand-name Rapamune, whose Western list price can reach several thousand dollars per month, the China-made Yixinke is priced far lower, making lifelong immunosuppression far more sustainable for patients. As a Hong Kong-licensed supplier, GLT provides a dependable channel for this China-made generic alongside the originator, with full batch documentation and transparent pricing.

How to Order Yixinke (Sirolimus)

To order Yixinke, contact our team on WhatsApp at +86 15234153837 or by email at [email protected]. Please share the required quantity and your destination country so we can confirm availability, documentation, and delivery terms.

FAQ

Is Yixinke a generic of Rapamune? Yes. Yixinke (宜欣可) is a bioequivalent domestic sirolimus produced by North China Pharmaceutical, an alternative to the originator Rapamune.

Who makes Yixinke? Yixinke is manufactured by North China Pharmaceutical Company, Ltd. (华北制药), a major state-owned Chinese pharmaceutical enterprise.

What strength is available? Yixinke is supplied in 0.5 mg tablets (20 per pack), which allows precise dose adjustment during treatment.

Does sirolimus require blood monitoring? Yes. Sirolimus dosing is adjusted based on whole-blood trough levels, so therapeutic drug monitoring is essential regardless of brand.