Rizonib (Crizotinib) 250mg Capsules | DIL Bangladesh Generic Xalkori for ALK+ NSCLC | GLT

Generic Information: Rizonib (Crizotinib) — Bangladesh

Rizonib is the crizotinib capsule produced by Drug International Ltd. (DIL), one of the longest-established generics manufacturers in Bangladesh, based in Tongi, Gazipur, near Dhaka. Each capsule contains crizotinib INN 250 mg, and the standard consumer pack holds 60 capsules. As a first-generation ALK/ROS1/MET tyrosine kinase inhibitor, crizotinib remains a widely referenced first-line targeted option for driver-gene-positive non-small cell lung cancer, and DIL's version brings this therapy to patients at a fraction of the originator's cost.

What Is Rizonib (Crizotinib) Used For?

Rizonib follows the internationally recognized crizotinib label: it is indicated for locally advanced or metastatic non-small cell lung cancer whose tumors test positive for an ALK rearrangement or a ROS1 rearrangement. The crizotinib molecule is additionally referenced worldwide for ALK-driven rare diseases — systemic anaplastic large cell lymphoma (ALCL) in patients one year and older, and unresectable, recurrent or refractory inflammatory myofibroblastic tumor (IMT). Bangladeshi oncologists prescribe Rizonib in exactly these settings, and international buyers frequently request it as a lower-cost alternative to Xalkori.

How Does Rizonib (Crizotinib) Work?

Crizotinib blocks three receptor tyrosine kinases at once: ALK (anaplastic lymphoma kinase), ROS1, and MET (hepatocyte growth factor receptor, c-Met). In ALK- or ROS1-positive tumors, chromosomal rearrangements create fusion genes that keep growth signaling permanently switched on. By occupying the ATP-binding pocket of these kinases, Rizonib's active ingredient interrupts the downstream signaling cascade, so malignant cells stop proliferating and are driven toward apoptosis. Because the same pathways matter in MET-exon-14 alterations and some pediatric tumors, researchers continue to map crizotinib's broader utility even as newer-generation inhibitors extend the sequence of therapy.

Indications of Rizonib

The approved indications mirrored on the Rizonib label are: metastatic NSCLC positive for ALK detected by an approved molecular test; metastatic NSCLC positive for ROS1; relapsed or refractory systemic ALCL in pediatric patients aged one year and older and in young adults; and unresectable, recurrent or refractory IMT with an ALK alteration in patients aged one year and older. Molecular pathology confirmation before starting therapy is standard practice, since none of these indications respond to crizotinib without the corresponding driver alteration.

Dosage and Administration

For adult NSCLC, the labeled regimen is one 250 mg capsule taken orally twice daily, roughly twelve hours apart, with or without food, continuing until disease progression or unacceptable toxicity. Capsules must be swallowed whole — never crushed, chewed or opened. Dose reductions follow the reference schedule: first step down to 200 mg twice daily, then to 250 mg once daily if further adjustment is required. Pediatric ALCL and IMT dosing is calculated from body surface area (about 280 mg/m² per day in divided doses), so families should confirm the exact pediatric schedule with the treating oncologist. Grapefruit and grapefruit juice should be avoided throughout treatment because they interfere with crizotinib metabolism.

Side Effects of Rizonib (Crizotinib)

The safety profile matches the global crizotinib database. Very common effects include visual disturbance (often described as a brief trailing of lights), nausea, diarrhea, vomiting, constipation, peripheral edema, elevated transaminases, fatigue and reduced appetite. Less common but clinically significant events are neutropenia and lymphopenia, QT-interval prolongation with bradycardia, drug-induced interstitial lung disease or pneumonitis, and meaningful hepatotoxicity. Oncology teams normally run baseline and periodic liver-function tests, full blood counts and ECGs. Patients should report sudden breathlessness, fever with cough, palpitations, visible jaundice or severe abdominal pain to their physician without delay.

Storage Instructions

Store Rizonib capsules below 30°C in the original container, protected from light and moisture, and out of reach of children. Do not use capsules from damaged blisters or an expired bottle, and return any unused medicine to a pharmacy for safe disposal rather than discarding it with household waste. No refrigeration is required.

Why Choose Rizonib from GLT?

DIL operates one of Bangladesh's largest production bases — the Tongi, Gazipur facility — and exports to dozens of countries under the country's WHO-aligned GMP framework, so Rizonib arrives with batch-level traceability that GLT verifies before dispatch. On cost, generic crizotinib from Bangladesh typically lands roughly 70%–80% below the US list price for the same monthly course, which is why patients from regions where the originator is unaffordable or unregistered ask for Rizonib by name. GLT supplies the 60-capsule DIL pack with cold-chain-safe ambient shipping, batch photographs on request, and documentation that customs and hospital pharmacies commonly ask for. Whether you are a family coordinating treatment or an institutional buyer comparing tenders, you receive the same verified-supply workflow and direct access to our team.

How to Order Rizonib (Crizotinib)

Ordering takes three steps: send your product inquiry with the required quantity, receive a formal quotation with shipping options and payment instructions, then confirm payment and delivery details so we dispatch with full documentation. Institutional buyers can request CoA and batch documents in advance. Reach GLT directly on WhatsApp +86 15234153837 or by email at [email protected] — both lines are monitored daily, and quotes for Rizonib usually go out within one working day.

FAQ

Is Rizonib the same as Xalkori? It contains the identical active molecule, crizotinib, at the same 250 mg strength; the difference is the manufacturer (Drug International Ltd. of Bangladesh) and the price.

How is Rizonib different from Crizocent? Both are Bangladeshi generic crizotinib capsules, but they come from different factories: Rizonib is made by DIL in Tongi, Gazipur, while Crizocent is Incepta's product from Savar, Dhaka. Quality standards and indications are equivalent; availability and pricing can differ.

What pack size does DIL offer? The standard export pack shown on the box is 60 capsules of 250 mg, i.e., a full month of twice-daily therapy in one container.

Do I need a prescription? Yes. Crizotinib is a prescription oncology medicine, and GLT expects buyers to have an oncologist overseeing therapy, molecular test results in hand, and a valid import pathway in their destination country.

Can you supply other crizotinib generics? Yes — GLT lists originator Xalkori from China and the USA plus several Bangladeshi and Laotian generics; message us for a side-by-side quotation so you can compare batch dates and landed cost.