Afinitor (Everolimus) 5mg Tablets | China-Sourced mTOR Inhibitor | GLT

Generic Information: Afinitor (Everolimus) — China Version

The China version of Afinitor delivers the same Novartis everolimus molecule that oncologists rely on worldwide, in the 5 mg × 30-tablet pack most commonly prescribed in Chinese hospitals. Everolimus is a selective mTOR inhibitor that Novartis first launched globally in 2009 and registered in China in 2013, where it is sold under the Chinese brand name 飞尼妥. The 5 mg strength is the workhorse dose for Chinese patients who need a reduced starting dose due to hepatic impairment or concomitant CYP3A4/P-glycoprotein inhibitor use, while still allowing escalation to 10 mg when tolerated.

What Is Afinitor (Everolimus) Used For?

In China, Afinitor (everolimus) is approved for the same broad oncology indications as elsewhere: advanced renal cell carcinoma after prior sunitinib or sorafenib, progressive pancreatic neuroendocrine tumors, non-functional gastrointestinal or lung neuroendocrine tumors, and TSC-associated renal angiomyolipoma and subependymal giant cell astrocytoma. It is also used in combination with exemestane for postmenopausal women with hormone receptor-positive, HER2-negative advanced breast cancer after letrozole or anastrozole.

How Does Afinitor (Everolimus) Work?

Everolimus works by binding FKBP-12 and inhibiting mTORC1, the central regulator of cell growth, protein synthesis, and angiogenesis. By shutting down this pathway, the drug starves tumor cells of the signals they need to proliferate and build blood vessels. This mechanism is especially relevant in renal cell carcinoma and neuroendocrine tumors, where the PI3K/AKT/mTOR axis is frequently deregulated.

Indications

The China version of Afinitor is indicated for: (1) advanced renal cell carcinoma in adults who have failed sunitinib or sorafenib; (2) unresectable, locally advanced or metastatic, well-differentiated progressive pancreatic neuroendocrine tumors; (3) progressive, well-differentiated, non-functional GI or lung neuroendocrine tumors; (4) TSC-associated renal angiomyolipoma not requiring immediate surgery; (5) TSC-associated SEGA not amenable to surgery; and (6) hormone receptor-positive, HER2-negative advanced breast cancer combined with exemestane.

Dosage

The standard dose is 10 mg once daily, but the 5 mg tablet is frequently used for dose reduction or as a starting dose in patients with moderate hepatic impairment. The tablet should be swallowed whole with water, with or without food, at the same time each day. For patients who cannot swallow, the tablet may be dispersed in 30 mL of water and taken immediately.

Side Effects

Common side effects include stomatitis, rash, fatigue, diarrhea, infection, nausea, and metabolic changes such as hyperglycemia and elevated cholesterol. Clinicians monitor for non-infectious pneumonitis and renal dysfunction, both of which require prompt attention. Patients should report persistent mouth ulcers, new cough, or breathlessness to their doctor.

Storage

Store Afinitor tablets below 30°C, protected from moisture and light, in the original packaging. Keep away from children and do not use after the printed expiry date.

Why Choose the China Version of Afinitor?

The China version of Afinitor offers the identical Novartis molecule at a price that is substantially lower than Western list prices. In China, everolimus is included in the national medical insurance drug list, and the 5 mg × 30-tablet pack is widely available through hospitals and licensed suppliers. Compared with the United States, where a monthly Afinitor supply can cost several thousand dollars, the China-sourced version is priced far lower — by a wide margin overall — while coming from the same manufacturer and the same GMP-quality supply chain. For patients and institutions seeking authentic originator everolimus at a more accessible cost, the China version is a practical, dependable choice.

How to Order Afinitor (Everolimus) from China

To order China-sourced Afinitor, contact our team on WhatsApp at +86 15234153837 or by email at [email protected]. We are a Hong Kong-licensed pharmaceutical supplier and can provide batch documentation and shipping support to your destination. Please share the required quantity and your country so we can confirm availability and delivery terms.

FAQ

Is Afinitor available in China? Yes. Afinitor (飞尼妥) has been registered in China and is widely available through hospitals and licensed suppliers.

What is the price of Afinitor in China? The China version is priced substantially lower than Western list prices, and everolimus is covered by the national medical insurance drug list in China.

Can I buy Afinitor from China? Yes, through a Hong Kong-licensed supplier such as GLT, which sources authentic China-registered Afinitor with full documentation.

How does the 5 mg strength fit into treatment? The 5 mg tablet is used for dose reduction in hepatic impairment or as a starting dose, with escalation to 10 mg when tolerated.