Kadcyla 赫赛莱 Ado-trastuzumab Emtansine (T-DM1) 100/160mg | Roche China Originator | GLT

Generic Information: Kadcyla 赫赛莱 (China)

This listing is the China-market presentation of Kadcyla, Roche's ado-trastuzumab emtansine, marketed locally under the Chinese trade name 赫赛莱 (Hesailai) and approved by the National Medical Products Administration. Supplied as 100 mg and 160 mg single-use vials of lyophilized powder, it was the first HER2-targeted antibody-drug conjugate approved in China, and it is the same reference molecule used in the United States, Europe and Switzerland.

What Is 赫赛莱 (Kadcyla) Used For?

赫赛莱 is approved in China for the adjuvant treatment of HER2-positive early breast cancer in patients who still have residual invasive disease after neoadjuvant therapy combining a taxane with trastuzumab. This is the population with the highest risk of recurrence, and the KATHERINE trial showed the medicine cut the chance of invasive recurrence or death by about half relative to continuing trastuzumab alone — the evidence behind its China approval.

How Does 赫赛莱 Work?

The drug is a "biological missile": the trastuzumab antibody latches onto HER2 receptors on cancer cells and carries a potent microtubule poison, DM1, directly inside them. Once internalized, the conjugate is digested in the cell's lysosomes and DM1 is released to disrupt the mitotic spindle, arresting cell division and triggering cell death. This targeted delivery concentrates the cytotoxic effect on HER2-positive tumour cells while limiting damage to normal tissue.

Indications

In China the approved indication is the adjuvant treatment of adults with HER2-positive early breast cancer who have residual invasive disease after neoadjuvant taxane-based and trastuzumab-based treatment. The medicine is used as monotherapy — it is not paired with additional chemotherapy in this setting. Confirmation of HER2 positivity by a validated assay is required before starting, since the drug's benefit depends on the target being present.

Dosage

The dose is 3.6 mg per kilogram given by intravenous infusion every 21 days, continued until the planned course is complete or unacceptable toxicity appears. The first dose is infused over 90 minutes and subsequent doses over 30 minutes when tolerated. With the 100 mg and 160 mg vials, the pharmacy calculates how many vials each patient's weight-based dose requires per cycle.

Side Effects

The most frequent side effects are fatigue, nausea, musculoskeletal pain, headache and reduced platelets. The important safety warnings are liver toxicity, heart dysfunction from a drop in left-ventricular ejection fraction, and fetal harm, so liver function and cardiac function are checked before and during therapy, and platelet counts are measured before each infusion.

Storage

赫赛莱 vials are stored refrigerated at 2°C to 8°C, protected from light, and are shipped as a cold-chain biologic. GLT dispatches from a Hong Kong-licensed facility using validated temperature-controlled logistics, with batch documentation and a certificate of analysis enclosed.

Why Choose 赫赛莱 Through GLT?

The China originator presentation carries Roche's reference-standard T-DM1 with NMPA provenance and full traceability. Because China is GLT's core supply base, this version is typically more accessible and competitively priced than Western-market presentations — a meaningful advantage for importers and hospital buyers who need the innovator ADC at scale.

How to Order

To order 赫赛莱 (Kadcyla, ado-trastuzumab emtansine) from GLT, contact us on WhatsApp at +86 15234153837 or by email at [email protected]. We confirm stock, vial size and cold-chain delivery timelines to your country, and dispatch from a Hong Kong-licensed facility.

FAQ

Is 赫赛莱 the same as Kadcyla? Yes — 赫赛莱 is the Chinese trade name for Roche's originator Kadcyla, with identical active ingredient and strengths.

What is it approved for in China? Adjuvant treatment of HER2-positive early breast cancer with residual disease after neoadjuvant taxane plus trastuzumab.

Does it require cold-chain shipping? Yes — it is refrigerated at 2°C to 8°C and travels by validated temperature-controlled logistics.