Tepmetko (Tepotinib) 225mg*60 | Merck KGaA China NMPA | GLT

Generic Information: Tepmetko (Tepotinib) 225mg — China-Mainland

This is the China-Mainland presentation of Tepmetko, the originator tepotinib from Merck KGaA (Darmstadt, Germany), supplied as 225 mg film-coated tablets in a 60-tablet box. Tepotinib was approved by China's NMPA for MET exon 14 skipping-mutated non-small cell lung cancer, and the medicine has since been included in China's national medical insurance scheme, where it is reimbursed for eligible patients. That reimbursement status makes the China version one of the more affordable originator tepotinib presentations globally.

The Chinese-language brand name is "拓得康" (Tepmetko), and the pack carries NMPA approval details alongside Merck branding. For cross-border buyers, the China version stands out because its reimbursed price is substantially below Western list prices — the core value proposition of sourcing through China.

What Is Tepmetko Used For?

Tepmetko treats advanced non-small cell lung cancer driven by the MET exon 14 skipping mutation, a rare driver alteration confirmed by molecular testing. It is indicated for adults with this mutation, in both the first-line and previously treated settings. Because it is an oral, once-daily targeted therapy, it offers a convenient alternative to infusion-based treatment for this molecularly defined group of patients.

How Does Tepmetko Work?

Tepotinib selectively blocks the MET receptor tyrosine kinase. The MET exon 14 skipping mutation removes the receptor's degradation signal, leaving MET persistently active and driving tumour growth. By inhibiting this overactive kinase, Tepmetko interrupts the proliferative signal. Its oral formulation and ability to penetrate the central nervous system make it well suited to patients with this mutation, including those with brain metastases.

Indications

• Metastatic non-small cell lung cancer with MET exon 14 skipping mutation, confirmed by a validated diagnostic test.
• Adult patients in first-line or later lines of therapy.

Dosage and Administration

Take Tepmetko 450 mg once daily — two 225 mg tablets together — with or without food, swallowed whole. A 60-tablet box covers one month of therapy. Dose adjustments or interruptions may be required for oedema or elevated liver enzymes, and liver function should be monitored during treatment.

Side Effects

Frequent adverse effects include peripheral oedema, nausea, diarrhoea, fatigue and reduced appetite. Liver enzyme elevations are a recognised, monitorable effect requiring periodic blood tests. Less common but serious risks include interstitial lung disease and QT interval prolongation; patients should promptly report new breathlessness, cough, palpitations or significant swelling.

Storage

Store below 30°C, in the original package, away from moisture and out of children's reach. Use before the expiry date printed on the box.

Why Choose the China Version of Tepmetko?

The China-Mainland Tepmetko stands out for its price: because it is nationally reimbursed, its effective cost is far below the list price of the same medicine in the United States and Germany — roughly half or lower, and meaningfully more affordable than in Japan and several European markets. For institutions and patients able to source through China, this is one of the most economical ways to access originator tepotinib without switching to a generic. GLT documents each batch and guides buyers through import requirements.

How to Order Tepmetko (China) from GLT

To order the China-Mainland Tepmetko 225 mg (60 tablets), message GLT on WhatsApp at +86 15234153837 or email [email protected]. State your quantity, destination and whether the order is personal or institutional. We confirm the current reimbursed China price, batch origin and required export documentation before dispatch.

FAQ

Is Tepmetko reimbursed in China? Yes, tepotinib (Tepmetko) is included in China's national medical insurance scheme for MET exon 14-mutated NSCLC, making the China presentation notably affordable.

Why is the China version cheaper? China's national reimbursement and price negotiation have brought the cost of Tepmetko well below Western list prices, so the China presentation is an economical originator option.

Can I buy China Tepmetko from outside China? GLT can help international buyers source the China presentation with proper export documentation; contact us on WhatsApp or email.