Tracleer (Bosentan) 125mg*56's | China-Sourced Endothelin Receptor Antagonist | GLT

Generic Information: Tracleer (China-Mainland)

This is the China-Mainland version of Tracleer, the Actelion brand of bosentan, an oral dual endothelin receptor antagonist. It is supplied as 125 mg film-coated tablets in a 56-tablet box, the standard maintenance strength for adults. In China the product is known by the Chinese brand name Quankeli (全可利). Bosentan was the world's first approved oral therapy for pulmonary arterial hypertension, and it remains a foundational treatment in this disease area today.

What Is Tracleer Used For?

Tracleer is used to treat pulmonary arterial hypertension (PAH), WHO functional class II to IV, to improve exercise ability and reduce clinical worsening. In China, the medicine is approved by the National Medical Products Administration (NMPA) and has been included in the national medical insurance drug list, which substantially lowers the out-of-pocket cost for eligible patients. The most common underlying causes in clinical trials were idiopathic or heritable PAH, PAH associated with connective tissue disease, and PAH associated with congenital heart disease.

How Does Bosentan Work?

Bosentan is a specific, competitive antagonist of endothelin receptors ETA and ETB. In patients with pulmonary arterial hypertension, levels of endothelin-1, a potent blood-vessel constrictor, are abnormally high, driving the narrowing and remodeling of the lung's blood vessels. By blocking both receptors, bosentan relaxes these vessels, lowers pulmonary vascular resistance, and reduces the workload on the right side of the heart. In the pivotal BREATHE-1 trial, bosentan improved six-minute walk distance by about 44 meters versus placebo and significantly delayed time to clinical worsening.

Indications

Tracleer is indicated for adults with pulmonary arterial hypertension (WHO Group 1), functional class II to IV, to improve exercise capacity and decrease clinical worsening. It is also approved for children aged three years and older with idiopathic or congenital PAH. The medicine is not a cure, but it slows disease progression and improves symptoms when taken as long-term, twice-daily therapy.

Dosage

The standard adult regimen starts at 62.5 mg twice daily for the first four weeks, then increases to the maintenance dose of 125 mg twice daily. The 125 mg tablets in this listing are used for the maintenance phase. The tablets are taken morning and evening, with or without food. Because bosentan can harm the liver and cause birth defects, liver aminotransferases must be measured before starting treatment and monthly thereafter, and women of childbearing potential must have a negative pregnancy test and use reliable contraception.

Side Effects

The most common adverse reactions include headache, flushing, fluid retention (edema), and abnormal liver function tests. Bosentan can also cause a dose-related drop in hemoglobin, so blood counts are monitored during treatment. The most serious risks are hepatotoxicity and embryo-fetal toxicity, which is why the medicine is available only through a restricted distribution program and requires monthly liver monitoring. Patients should report signs of fluid retention or new breathing problems promptly.

Storage

Store Tracleer tablets at room temperature, between 15°C and 30°C, in the original container, away from moisture, and out of the reach of children. No refrigeration is required.

Why Choose the China Version of Tracleer?

The China version of Tracleer is the same Actelion molecule sold in Western markets, but its reimbursed price is markedly lower than the list price of the same branded medicine in the United States. For patients eligible for China's national medical insurance, the effective monthly cost can be a fraction of what the brand would cost out of pocket in the United States or Europe. This makes China-sourced Tracleer an attractive route to genuine Actelion bosentan at a more accessible price point.

How to Order

To source China-Mainland Tracleer through GLT, contact us on WhatsApp at +86 15234153837 or email [email protected]. Tell us the strength and pack size you need and your destination country, and we will confirm sourcing origin, current availability, and the export documentation required for import. We serve both institutions and individual patients.

FAQ

Is bosentan available in China? Yes, bosentan is approved in China by the NMPA and is available through the national medical insurance system as a reimbursed medicine.

Is the China version cheaper than the US version? Generally yes. The reimbursed China price is substantially lower than the US list price, which is why many international buyers consider sourcing from China for genuine Actelion bosentan.

What is the difference between Tracleer China and Tracleer Switzerland? The active ingredient and dosage are identical; the difference is the packaging, the regulatory market, and the price. Both are genuine Actelion products.